发给老马备查:' w6 h2 D5 }( \, D2 `
滴水察海(69304838) 15:23:23, K4 q- I1 t: r5 {
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
: r* e( }7 U( \吉非替尼和S-1连用的依据
) j# p4 F, e( e% Y, g, OGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
8 D/ L8 @2 j) ?1 N: V! ~是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达; W0 B: a) L& _1 ?
这样是不是推理出,耐药后,可以用S-1和培美了?
( x5 Z1 ?& m2 B; w. C0 d5 W结论:
+ @' t E4 b: V( k2 X5 e如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |