发给老马备查:6 I _9 ]- s; w1 A
滴水察海(69304838) 15:23:238 z+ F% M; @% O F5 D
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
% Q- S* }9 Q: ?吉非替尼和S-1连用的依据
]& C$ j% T9 C; f) n' @, LGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
7 A% I; g6 C i是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
6 B6 M" p; c! b2 p' z这样是不是推理出,耐药后,可以用S-1和培美了?
; M+ f- i' A$ J/ ?' V! P结论:+ P' }, X. N/ \
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |