发给老马备查:
1 P* X, S# y, U: J$ ?& |/ Q9 b滴水察海(69304838) 15:23:236 `- t) t' ]* J. Q) c, P5 j
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
4 Y7 X* N& q/ Z: {0 F& M x吉非替尼和S-1连用的依据2 e+ Z: W8 Z: U: e
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
Z: `8 Z. l6 h! W. A9 C; \是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达* w3 z9 R7 ?; J3 w7 X
这样是不是推理出,耐药后,可以用S-1和培美了?
2 R2 u' a# b" w) V4 i4 U结论:" w6 j b1 u u' B" a$ [7 {# t. O
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |