发给老马备查:3 t8 x: Y- C+ _
滴水察海(69304838) 15:23:23
1 |. Q" g/ \, v+ G老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
" R- I& t8 }: r3 _& [吉非替尼和S-1连用的依据 e8 J5 S, \5 S7 D" m% I6 t
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
: Z: w1 \) {# U8 O' t4 h是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达- d! |$ D. j) Z+ q7 F, p+ { d
这样是不是推理出,耐药后,可以用S-1和培美了?
9 N3 F Z# i; e& J% b3 M' I, W2 V结论:
; X, U! U8 Y# V. x1 I& S如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |