发给老马备查:, R1 J/ d; ^! A. a/ A
滴水察海(69304838) 15:23:23
! L3 v5 b1 r+ B老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
( s+ p! x* Z6 @6 y% Z; G% s吉非替尼和S-1连用的依据1 j5 ^4 ~ Z0 H3 s* c
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.# G9 e& M8 ` R' @- J6 z: F6 @, L5 J
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达4 C" ]$ d, e1 N& j
这样是不是推理出,耐药后,可以用S-1和培美了?! t- D% P' @# W% L' |% y+ A+ |
结论:
, t w1 Q. ]' H' P6 e* B( B如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |