老马,我家6月确诊肺腺,6月份正版帕唑帕尼 ct基本无变化; {8 \: K, l% Q) }/ o& Q, c0 R
7月份易瑞沙 主灶基本无变化,胸膜转移灶增大 / E. M" ^1 ]1 k 8月份易瑞沙 主灶基本无变化,出现少量胸水 ) {9 P* [; R2 g7 a2 ` 9~10月中药 ct主灶大了近一倍,胸水增多,右下肺部分压缩不张% p' L7 p$ c. L2 @3 Y
11月份阿西替尼 ct胸水增多,几乎到胸腔一半的位置了,/ h. s- T0 F+ Q9 w K/ e
其他与10月份ct无变化9 Z) i2 \, m' t
现在吃了7天特, 咳嗽比较厉害. x, p1 ~0 P R
如不吃特,请问老马有什么建议?
Clinical response to a lapatinib-based therapy of a Li-Fraumeni Syndrome patient with a novel HER2-V659E mutation% Z) ]* _% T9 I9 l
Genomic characterization of recurrent breast and lung tumors developed over the course of 10 years in a 29-year-old patient with a germline p53 mutation (Li-Fraumeni Syndrome) identified oncogenic alterations in the HER2 and EGFR genes across all tumors, including HER2 amplifications, an EGFR-exon 20 insertion, and the first-in-human HER2-V659E mutation showing a phenotypic convergent evolution towards HER2 and EGFR alterations. Following the identification of HER2-activating events in the most recent lung carcinoma and in circulating tumor cells, we treated the reminiscent metastatic lesions with a lapatinib-based therapy. A clinical response both symptomatic and radiologic was achieved. HER2-V659E sensitivity to lapatinib was confirmed in the laboratory.