耐药之后的技术分析---从入门到精通系列之四

新咖啡男人 发表于 2014-9-11 21:51
克药的情况 ，好像停药后 更危险   ，吃克药的 ，就不要随便停

Third option: Keep the TKI going with the new chemo
第三种观点  配合化疗  

新咖啡男人 发表于 2014-9-11 21:53
Third option: Keep the TKI going with the new chemo
第三种观点  配合化疗

But, no advantage for PFS or OS
不过 PFS没有受益  

新咖啡男人 发表于 2014-9-11 21:56
But, no advantage for PFS or OS
不过 PFS没有受益

When chemo used, it’s worth coming back to TKI later

进来学习

新咖啡男人 发表于 2014-9-11 21:59
When chemo used, it’s worth coming back to TKI later

Systemic options other than chemo: Combination trials and 3rd generation TKIs       
系统化的观点 超过 化疗 ，联合治疗和三代的 TKI药物  

3rd generation TKIs: CO1686, AZD9291, HM61713, EGFR816, ASP8273: Look promising, but most requires repeat biopsy (more on this in next talk from Dr. Sequist).  More on 3rd gen TKI from Dr. Pasi Janne in afternoon breakout session
这些药不用我翻译吧   9291  1686  


Combination trials: Afatinib/cetuximab farthest along; AUY922/erlotinib, MET inhibitor/EGFR TKI, others.  More on combo trials from Dr. Melissa Johnson at afternoon breakout session)
AUY922 (NVP-AUY922)是一种高效的HSP90抑制剂，其对HSP90α/β的IC50为13 nM
Other trials: Any active agent can be considered including immunotherapy.

Kick the can down the road 抛开问题
Local ablation消融 切除 of spots that are growing then restart TKI
Chemo + TKI   化疗和TKI
Chemo alone (but, must start quickly after stopping TKI and reconsider TKI later)化疗
Combination Therapies 联合治疗
3rd Generation TKIs  三代TKI   
Other clinical trials

学习了~ O(∩_∩)O谢谢

好吧，我承认我笨！表示完全看不懂

本人英语水平太差

挑着中文看，主要意思大咖写得很明白了。谢谢楼主辛勤付出{:soso_e160:}