还没做过化疗，EGFR是野生型的病友一定要去做ALK的检测

jzjqian 发表于 2012-7-25 15:45

                               
登录/注册后可看大图

请教，像我这样的，手术22个月了，还能去原手术医院拿到病理作EGFR检查么？

" P4 T0 @0 h4 b* o& i5 ^可以，但要有针对性，

请问，肺鳞癌，只做过一次化疗，骨髓抑制严重，后吃特罗凯4个月基本无效，可以参加实验组吗？

不可以了,要没做过任何治疗的,包括化疗和靶向药

Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer.  Print this page  


Sub-category:
Molecular Targets

3 I# ]8 I/ l9 o7 w! f; {7 x
3 X, Y& u, I: ~2 l( _Category:
Tumor Biology
' ]+ ^3 W9 P8 w  W
$ U: H' L4 _: h4 l, R  F+ h
Meeting:
2011 ASCO Annual Meeting
" g) \9 q: y* b4 u9 O
" l- [2 Q- C4 k0 a7 ]6 B6 v: J
2 s1 D! \$ \5 YSession Type and Session Title:
  m2 w: G- I# M4 m' Q) k3 j5 LPoster Discussion Session, Tumor Biology


, H# L5 B$ q8 e' _6 S9 fAbstract No:
1 S$ G0 n  G0 O7 e5 {: Q- A1 g10517


2 a, @6 _2 r  S1 P  K: t$ MCitation:
5 e& t5 C! k3 [J Clin Oncol 29: 2011 (suppl; abstr 10517)

: R7 [# o7 K2 }6 V
3 ~% U( ^  O5 wAuthor(s):
J. Yang, X. Zhang, J. Su, H. Chen, H. Tian, Y. Huang, C. Xu, Y. L. Wu; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China; Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital, Guangzhou, China; Guangdong Lung Cancer Institute, Guangzhou, China; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China
0 N* }0 }: w* [( H; W: k
/ J0 Y7 B$ p/ t4 R
+ Q% y# W; N# B* y" L" q' }: m8 A- ?  B
7 M* |, Z8 t8 nAbstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy are designated with a caret symbol (^) here and in the printed Proceedings.
% X+ [+ K' Q) @: s! \5 B' J, H: x( L8 t
8 s% e/ d+ X) Y0 e1 N0 b/ aAbstract Disclosures
) i0 @8 G! L6 o6 Y7 K" b( F
9 f1 j) |: t: b7 c6 P6 nAbstract:


% }. w# n/ q7 r* k% ^Background: The fusion of the anaplastic lymphoma kinase (ALK) with the echinoderm microtubule-associated protein-like 4 (EML4) and epidermal growth factor receptor (EGFR) mutations are considered mutually exclusive. Advanced non-small cell lung cancer (NSCLC) patients with EML4-ALK did not benefit from EGFR tyrosine kinase inhibitors (TKIs). Methods: Multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) followed by sequencing was performed for EML4-ALK fusion status detection. EGFR and KRAS mutations were determined by direct DNA sequencing. Positive results of EML4-ALK fusion were also confirmed by RACE-coupled PCR sequencing. Results: From April 2010 to January 2011, 412 patients (398 with NSCLC; 14 with SCLC) were tested for mutation status of EGFR, KRAS and EML4-ALK respectively. Frequency of EML4-ALK fusion was 10.6% (42/398) in NSCLC patients. No patients with SCLC were found to have positive EML4-ALK fusion. Frequency of concomitant EGFR and EML4-ALK gene mutations was 1.0% (4/398) in NSCLC patients, and their variants of EML4-ALK gene mutations were Variant 1 (3 patients) and Variant 6 (1 patient); being never smokers, all of them were diagnosed with advanced (3 with stage †W and 1 with stage IIIB) adenocarcinoma harbouring wild type KRAS. Two female stage †W patients with double gene mutations (1 with L858R and Variant 1; 1 with exon19 deletion and Variant 6) received first-line gefitinib which is one kind of EGFR TKIs and achieved partial response. Conclusions: Though being rare events, NSCLC patients harbouring concomitant EGFR mutation and EML4-ALK gene fusion are sensitive to first-line EGFR TKIs. Whether they could also benefit from ALK inhibition after failure to EGFR TKIs warranted further investigation.


* B$ M& j: ~6 k& A. O( R: x( ^

由吴一龙教授牵头的A80810029临床试验上周启动，初诊未治疗的晚期肺腺癌患者检测到ALK阳性，可参加一线crizotinib 对比力比泰+卡铂的临床研究，药物全部免费，即使分配到力比泰组，疾病进展之后可免费获得crizotinib.

没有手术，只化疗过，现吃靶向药，未突变，alk未测，有机会入组吗？

boeun 发表于 2012-11-18 16:37

3 ^3 _: {. Z, P: F! C6 I8 k! C                               
登录/注册后可看大图

没有手术，只化疗过，现吃靶向药，未突变，alk未测，有机会入组吗？

化疗过的没机会了

平安！ 发表于 2012-7-20 11:20

' [5 G' K9 J' t+ e3 e: w                               
登录/注册后可看大图

6 P1 Z' a9 z( h& {" g易瑞沙、特罗凯有效的病人基本上可以断定ALK（-）。极其罕见EGFR、ALK同时突变的。
: f; p8 c( O3 DALK一个指标医院要900多 ...

8 [# `7 z* t# f( W9 L! `平安，真的没有希望吗？我弟弟虽然特罗凯有效，但是ＥＧＦＲ是野生型，不是突变啊。有没有必要去检测ＡＬＫ呢？
: R  r7 D8 X3 ~# C. _. d4 G6 S
现在病情进展，快没招儿了。

好像想加入挺困难的

小地方没条件做啊